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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
46.06
Human Site:
Y633
Identified Species:
72.38
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
Y633
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
Y633
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
Y633
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
Y670
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
Rat
Rattus norvegicus
P11345
648
72910
Y532
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
Y665
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
Chicken
Gallus gallus
Q04982
806
89347
Y673
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
Frog
Xenopus laevis
P09560
638
71941
V522
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
Y643
R
L
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
Y644
R
L
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
Fruit Fly
Dros. melanogaster
P11346
782
88616
Y648
R
M
Q
E
L
N
P
Y
S
F
Q
S
D
V
Y
Honey Bee
Apis mellifera
XP_396892
715
80060
E593
A
F
G
V
V
L
F
E
L
L
S
G
Q
L
P
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
Y662
R
M
Q
D
D
N
P
Y
T
P
Q
S
D
V
Y
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
Y616
R
M
R
D
T
N
P
Y
S
F
Q
S
D
V
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
P671
Y
L
H
N
R
N
P
P
I
V
H
R
D
L
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
100
N.A.
100
20
N.A.
100
100
6.6
93.3
93.3
86.6
0
80
86.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
40
N.A.
100
100
20
100
100
93.3
6.6
86.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
67
7
7
7
0
0
0
0
0
80
0
0
% D
% Glu:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% E
% Phe:
7
14
7
7
0
0
7
0
0
67
0
0
0
0
0
% F
% Gly:
0
0
7
0
0
0
0
0
0
0
7
14
0
0
0
% G
% His:
0
0
7
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
7
0
0
7
7
0
0
% I
% Lys:
0
0
0
0
54
0
0
0
0
0
0
0
0
0
7
% K
% Leu:
0
20
0
0
7
7
0
0
7
7
0
0
0
20
7
% L
% Met:
0
60
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
80
0
0
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
80
7
0
7
0
0
0
0
7
% P
% Gln:
0
0
67
7
7
0
0
0
0
0
74
0
7
0
0
% Q
% Arg:
74
0
7
0
7
0
0
0
0
0
0
7
0
0
0
% R
% Ser:
0
7
7
0
7
7
0
0
74
7
7
74
0
0
0
% S
% Thr:
0
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% T
% Val:
0
0
0
7
7
0
7
7
0
7
0
0
7
80
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
80
7
7
7
0
0
0
80
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _